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Preface vii List of Contributors ix Foreword xiii Abbreviations xvii Section I: Background 1 1 A Brief History of Particle Radiotherapy 3 2 The Physics of Particle Therapy 11 3 The Radiobiology of Particle Therapy 27 4 Practical Aspects of Particle Therapy Accelerators 47 5 Treatment Planning for Scanning Beam Proton Therapy 55 6 Image-Guided Particle Therapy and Motion Management 81 7 Advanced Particle Therapy Delivery: A Review of Advanced Techniques for Particle Therapy Delivery 101 8 FLASH Radiotherapy 115 9 Boron Neutron Capture Therapy 121 10 Grid Therapy 137 11 Particle Therapy and the Immune System 151 12 The Economics of Particle Therapy 165 Section II: Particle Therapy by Clinical Indication 177 13 Intracranial Tumors: Principles and Practice of Particle Therapy 179 14 Ocular Malignancies 201 15 Brain, Skull Base, and Spinal Tumors 225 16 Head and Neck Cancers 239 17 Thoracic Malignancies: Proton Beam and Carbon-ion Therapy for Thoracic Cancers and Recurrent Disease 261 18 Gastrointestinal Tumors 287 19 Hepatobiliary Cancers 311 20 Breast Cancer 357 21 Prostate Cancer 383 22 Non-prostate Genitourinary Cancers 411 23 Gynecologic Cancers 425 24 Lymphoma and Leukemia 445 25 Sarcomas and Soft Tissue Malignancies 465 26 Pediatric Central Nervous System Tumors 483 27 Particle Therapy for Non-CNS Pediatric Malignancies 495 Index 521