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By Manfred Auer. Author Manfred Auer. Biological systems are inherently complex with a large number of components needed to sustain cellular function. To grasp the link of such changes to physiological cell and tissue function and/or pathogenesis/disease progression, we need to understand how modifications alter macromolecular function, macromolecular interactions, and/or spatiotemporal distribution and overall supramolecular structural organization.
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